BOTHELL, WA--(Marketwire - 09/14/09) - AVI BioPharma, Inc. (NASDAQ: AVII - News ), a developer of RNA-based drugs, today announced the presentation of data regarding the Company's antisense technology for control of the immune response in hemorrhagic virus infections, including Ebola and Marburg virus, at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco, CA.
Patrick L. Iversen, Ph.D., Senior Vice President of Strategic Alliances, presented data from preclinical studies demonstrating that specific peptide conjugated phosphorodiamidate morpholino oligomers (PPMO) targeting innate and adaptive immune responses can diminish hemorrhagic viral pathogenesis and dramatically increase host survival rates in mouse lethal challenge studies. The experimental design involved injection of PPMO into mice 4 hours prior to infection with a mouse-adapted Ebola Zaire virus. Results demonstrated that treatment with a PPMO targeting the IL-10 exon 4 splice acceptor resulted in an average 60 percent survival (41 survivors in 70 challenged and treated mice) and, in one experiment, 100 percent survival (10 survivors of 10 infected and treated mice), whereas untreated controls showed only 18 +/- 16 percent survival (N=220). In separate experiments, treatment with this PPMO also provided for 90 percent survival in a Marburg lethal challenge mouse model.
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